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RBX1 抗体 (AA 1-70) (FITC)

This anti-RBX1 antibody is a 兔 多克隆 antibody detecting RBX1 in WB, IF (cc) 和 IF (p). Suitable for 人 和 小鼠.
产品编号 ABIN1398818
发货至: 中国

Quick Overview for RBX1 抗体 (AA 1-70) (FITC) (ABIN1398818)

抗原

See all RBX1 抗体
RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

适用

  • 52
  • 32
  • 10
  • 4
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  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
人, 小鼠

宿主

  • 38
  • 14

克隆类型

  • 37
  • 15
多克隆

标记

  • 33
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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This RBX1 antibody is conjugated to FITC

应用范围

  • 45
  • 18
  • 14
  • 12
  • 12
  • 11
  • 8
  • 8
  • 6
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

    • 14
    • 10
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-70

    交叉反应

    人, 小鼠

    预测反应

    Rat,Cow

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human ROC1/RNF75

    亚型

    IgG
  • 应用备注

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    RBX1 (Ring-Box 1, E3 Ubiquitin Protein Ligase (RBX1))

    别名

    RNF75

    背景

    Synonyms: E3 ubiquitin-protein ligase RBX1, MGC13357, MGC1481, Protein ZYP, Rbx 1, Rbx1, RBX1_HUMAN, Regulator of Cullins 1, Ring box 1, RING box protein 1, RING finger protein 75, RING finger protein, RING-box protein 1, Ringbox protein 1, RNF 75, RNF75, ROC 1, ZYP protein.

    Background: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

    基因ID

    9978

    途径

    Cell Division Cycle, M Phase, SARS-CoV-2 Protein Interactome
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