Contactin 3/4/5/6 (AA 181-280) 抗体 (AbBy Fluor® 488)
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北京 101111
Quick Overview for Contactin 3/4/5/6 (AA 181-280) 抗体 (AbBy Fluor® 488) (ABIN1392442)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 181-280
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预测反应
- Human,Mouse,Rat,Dog,Sheep,Pig,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Contactin 4
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Contactin 3/4/5/6
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背景
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Synonyms: AXCAM, axonal-associated cell adhesion molecule, BIG 2, BIG2, Brain-derived immunoglobulin superfamily protein 2, CNTN4, CNTN4A, CNTN4_HUMAN, CNTN6, CNTN6_HUMAN, Contactin 4, Contactin4, Contactin-4, Contactin-6, Contactin6, Contactin 6, hNB-3, NB3, neural cell adhesion protein BIG-2, Neural recognition molecule NB-3, Contactin-3, Brain-derived immunoglobulin superfamily protein 1, BIG-1, Plasmacytoma-associated neuronal glycoprotein, CNTN3, KIAA1496, PANG, Contactin-5, Neural recognition molecule NB-2, hNB-2, CNTN5
Background: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
抗原
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