DUSP6 抗体 (FITC)
Quick Overview for DUSP6 抗体 (FITC) (ABIN1391912)
抗原
See all DUSP6 抗体适用
宿主
克隆类型
标记
应用范围
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by Protein A.
-
免疫原
- KLH conjugated synthetic peptide derived from human DUSP6
-
亚型
- IgG
-
-
-
-
应用备注
-
IF(IHC-P): 1:50-200
Optimal working dilution should be determined by the investigator. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
-
有效期
- 12 months
-
-
-
Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." in: Hepatology (Baltimore, Md.), (2015) (PubMed).
: "
-
Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." in: Hepatology (Baltimore, Md.), (2015) (PubMed).
-
- DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))
-
别名
- Dusp6/Mkp-3
-
背景
-
Synonyms: Dual specicity phosphatase 6, Dual specicity phosphatase 6 isoform a, Dual specicity protein phosphatase 6, Dual specicity protein phosphatase PYST1, DUS6_HUMAN, DUSP 6, DUSP 6a, Dusp6, DUSP6a, MAP kinase phosphatase 3, Mitogen activated protein kinase phosphatase 3, Mitogen-activated protein kinase phosphatase 3, MKP 3, MKP-3, MKP3, PYST 1, PYST1, Serine/threonine specic protein phosphatase.
Background: Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4. Human MKP-3 maps to chromosome 12q22-q23 and encodes a 381 amino acid protein that specifically inactivates members of the ERK family and is expressed in a variety of tissues with the highest levels in heart and pancreas.
-
基因ID
- 8642
-
途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
-