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Complexin 1 抗体 (AA 31-100) (Biotin)

This anti-Complexin 1 antibody is a 兔 多克隆 antibody detecting Complexin 1 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 小鼠 和 大鼠.
产品编号 ABIN1390699
发货至: 中国

Quick Overview for Complexin 1 抗体 (AA 31-100) (Biotin) (ABIN1390699)

抗原

See all Complexin 1 (CPLX1) 抗体
Complexin 1 (CPLX1)

适用

  • 33
  • 24
  • 22
小鼠, 大鼠

宿主

  • 47
  • 1
  • 1

克隆类型

  • 49
多克隆

标记

  • 17
  • 5
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Complexin 1 antibody is conjugated to Biotin

应用范围

  • 32
  • 18
  • 16
  • 13
  • 13
  • 6
  • 5
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 16
    • 14
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 31-100

    交叉反应

    小鼠, 大鼠

    预测反应

    Human,Cow,Pig,Chicken

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human CPLX1

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    Complexin 1 (CPLX1)

    别名

    CPLX1

    背景

    Synonyms: complexin 1, Complexin I, Complexin-1, CPLX1, CPLX1_HUMAN, CPX I, CPX-I, CPX1, Synaphin 2, Synaphin-2, 921-S.

    Background: Complexin 1 and Complexin 2, also designated Synaphin 1 and Synaphin 2, contain an a-helical middle domain of approximately 58 amino acids. Complexin 1 and Complexin 2 are expressed in presynaptic terminals of inhibitory and excitatory hippocampal neurons, respectively, and in cytoplasmic pools during early stages of development. Complexins promote SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) precomplex formation by binding to synaxin with its a-helical domain. Complexins are important regulators of transmitter release at a late step in calcium dependent neurotransmitter release or immediately after the calcium-triggering step of fast synchronous transmitter release and preceding vesicle fusion. Neurons lacking complexins show reduced transmitter release efficiency due to decreased calcium sensitivity of the synaptic secretion process. Complexin 2 may play a role in LTP (long term potentiation) following tetanic stimulation. A progressive loss of Complexin 2 occurs in the brains of mice carrying the Huntington disease mutation, an autosomal dominant neurodegenerative disorder. Changes in the neurotransmitter release might contribute to the motor, emotional and cognitive dysfunctions seen in these mice.

    途径

    Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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