Hsp 40-4/Hdj2/Dnaja1 (AA 21-110) 抗体 (AbBy Fluor® 647)
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北京 101111
Quick Overview for Hsp 40-4/Hdj2/Dnaja1 (AA 21-110) 抗体 (AbBy Fluor® 647) (ABIN1390314)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-110
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Cow,Sheep,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human HSP 40-4
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Hsp 40-4/Hdj2/Dnaja1
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背景
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Synonyms: DJ 2, DJ2, DjA1, DnaJ Hsp40 homolog, subfamily A, member 1, DnaJ homolog subfamily A member 1, DnaJ protein homolog 2, DNAJ2, Dnaja1, DNJA1_HUMAN, hDJ 2, HDJ-2, HDJ2, Heat shock 40 kDa protein 4, heat shock protein DNAJ like 2, Heat shock protein J2, HSDJ, HSJ-2, HSJ2, HSPF4, Human DnaJ protein 2, NEDD7, Neural precursor cell expressed developmentally down regulated 7, OTTHUMP00000021193.
Background: DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
抗原
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