MTMR14 抗体 (AA 161-260) (FITC)
Quick Overview for MTMR14 抗体 (AA 161-260) (FITC) (ABIN1389968)
抗原
See all MTMR14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-260
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MTMR14
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亚型
- IgG
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anti-Myotubularin Related Protein 14 (MTMR14) antibody
MTMR14 适用: 人, 大鼠, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 6B6 unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 1-280) antibodyMTMR14 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 1-280) antibodyMTMR14 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 1-280) antibodyMTMR14 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) antibodyMTMR14 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 614-647) antibodyMTMR14 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB52012 unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 1-529) antibodyMTMR14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 1-417) antibodyMTMR14 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3B11 unconjugated
anti-Myotubularin Related Protein 14 (MTMR14) (AA 395-444) antibodyMTMR14 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, Pig, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MTMR14 (Myotubularin Related Protein 14 (MTMR14))
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别名
- MTMR14
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背景
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Synonyms: C3orf29, Egg derived tyrosine phosphatase homolog, FLJ11546, FLJ22405, FLJ46453, FLJ90311, HCV NS5A transactivated protein 4 splice variant A binding protein 1, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy, jumpy, MTMR 14, MTMR14, MTMR-14, MTMRE_HUMAN, Myotubularin related protein 14, Myotubularin-related protein 14, NS5ATP4ABP1.
Background: Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).
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途径
- Inositol Metabolic Process
抗原
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