Neuronatin (NNAT) (AA 31-81) 抗体
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Quick Overview for Neuronatin (NNAT) (AA 31-81) 抗体 (ABIN1387892)
抗原
See all Neuronatin (NNAT) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-81
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交叉反应
- 人, Pig, 大鼠
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预测反应
- Mouse,Cow,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Neuronatin
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亚型
- IgG
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anti-Neuronatin (NNAT) (AA 22-81) antibody
NNAT 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1B9 unconjugated
anti-Neuronatin (NNAT) (Middle Region) antibodyNNAT 适用: 人, 大鼠, 小鼠, Cow, 犬, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Oocyte aging-induced Neuronatin (NNAT) hypermethylation affects oocyte quality by impairing glucose transport in porcine." in: Scientific reports, Vol. 6, pp. 36008, (2018) (PubMed).
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: "Oocyte aging-induced Neuronatin (NNAT) hypermethylation affects oocyte quality by impairing glucose transport in porcine." in: Scientific reports, Vol. 6, pp. 36008, (2018) (PubMed).
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- Neuronatin (NNAT)
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别名
- Neuronatin
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背景
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Synonyms: Neuronatin, Nnat, NNAT_HUMAN, Peg 5, Peg5.
Background: The paternally imprinted Neuronatin gene (NNAT) is initially expressed in rhombomeres and the pituitary gland and is later expressed more widely, but much less abundantly, in the central and peripheral nervous systems. The human NNAT gene maps to chromosome 20q11.23 and contains an imprinting region associated with morphological abnormalities and early neonatal lethality. Specifically, hypermethylation of the NNAT gene occurs in both myeloid and lymphoid acute pediatric leukemias and may inhibit NNAT expression. The Neuronatin protein consists of two isoforms, alpha and beta, which are the products of alternative splicing. The alpha form of the Neuronatin gene is encoded by three exons, whereas the beta form is missing the second exon. Neuronatin mRNA expression is abundant in undifferentiated PC-12 cells. Treatment of these cells with nerve growth factor (NGF), which contributes to neuronal differentiation, downregulates Neuronatin mRNA expression. NNAT (-) 1.9 PC-12 cells exhibit an increase in nigericin, rotenone and valinomcin sensitivity, NNAT transfection restores wild-type PC-12 resistance. These results suggests a potential protective role for Neuronatin against toxic insult during development.
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基因ID
- 4826
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UniProt
- Q16517
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途径
- Positive Regulation of Peptide Hormone Secretion
抗原
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