UBE2D3 抗体 (AA 55-147)
Quick Overview for UBE2D3 抗体 (AA 55-147) (ABIN1387890)
抗原
See all UBE2D3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 55-147
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Cow,Pig,Horse,Chicken,Rabbit,Zebrafish
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human UBE2D3
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亚型
- IgG
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anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (N-Term) antibody
UBE2D3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-147) antibodyUBE2D3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C1-1E3 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-147) antibodyUBE2D3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) antibodyUBE2D3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (N-Term) antibodyUBE2D3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 小鸡, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-100) antibodyUBE2D3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 109-136), (C-Term) antibodyUBE2D3 适用: 人 WB 宿主: 兔 Polyclonal RB36300 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
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别名
- UBE2D3
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背景
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Synonyms: E217KB3, MGC43926, MGC5416, UB2D3_HUMAN, UBC 4/5, UBC4/5, UBC4/5 homolog yeast, UBCH 5C, UBCH5C, Ube2d3, Ubiquitin carrier protein, Ubiquitin carrier protein D3, Ubiquitin conjugating enzyme E2 17 kDa 3, Ubiquitin conjugating enzyme E2 D3, Ubiquitin conjugating enzyme E2D 3 homologous to yeast UBC4/5, Ubiquitin conjugating enzyme E2D 3 UBC4/5 homolog yeast, Ubiquitin conjugating enzyme E2D 3, Ubiquitin protein ligase D3, Ubiquitin-conjugating enzyme E2 D3, Ubiquitin-conjugating enzyme E217KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3.
Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
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基因ID
- 7323
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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