DOCK3 抗体 (AA 1001-1100)
Quick Overview for DOCK3 抗体 (AA 1001-1100) (ABIN1387818)
抗原
See all DOCK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1001-1100
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预测反应
- Human,Mouse,Rat,Dog,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DOCK3
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亚型
- IgG
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anti-Dedicator of Cytokinesis 3 (DOCK3) (AA 1630-1934) antibody
DOCK3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- DOCK3 (Dedicator of Cytokinesis 3 (DOCK3))
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别名
- DOCK3
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背景
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Synonyms: Dedicator of cytokinesis protein 3, DOCK 3, MOCA, Modier of cell adhesion, Presenilin binding protein, DOCK3_HUMAN.
Background: MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.
抗原
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