SERPINE2 抗体 (AA 301-398)
Quick Overview for SERPINE2 抗体 (AA 301-398) (ABIN1387740)
抗原
See all SERPINE2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 301-398
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GDN/SERPINE2
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亚型
- IgG
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- SERPINE2 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 2 (SERPINE2))
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别名
- GDN
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背景
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Synonyms: Glia derived nexin, Protease inhibitor 7, GDN, GDN_HUMAN, Glia-derived nexin, P17 antibody Peptidase inhibitor 7, Pi-7, Plasminogen activator inhibitor type 1, member 2, PN-1, PN1, PNI, Protease nexin 1, Protease nexin I, Serpin E2, Serpin peptidase inhibitor, clade E nexin, plasminogen activator inhibitor type 1, member 2, SERPINE 2, Serpine2.
Background: The serine protease inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Protease nexin-1 (PN-1) is a serpin that inactivates several proteases, including thrombin, urokinase, plasminogen activators (PA) and plasmin. It is involved in tissue remodeling, cellular invasiveness, matrix degradation and tumor growth. PN-1 expression is abundant in the nervous system, where it inhibits thrombin, thereby playing a role in neural injury and repair processes. An imbalance between PN-1 and thrombin may be a contributing factor in the pathology of Alzheimer??s disease.
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基因ID
- 5270
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UniProt
- P07093
抗原
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