HIP1 抗体 (AA 401-500)
Quick Overview for HIP1 抗体 (AA 401-500) (ABIN1387494)
抗原
See all HIP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 401-500
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预测反应
- Human,Mouse,Rat,Dog,Horse,Chicken,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human HIP1
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亚型
- IgG
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anti-Huntingtin Interacting Protein 1 (HIP1) (AA 928-1037) antibody
HIP1 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 1F12 unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 410-690) antibodyHIP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 928-1037) antibodyHIP1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 928-1038) antibodyHIP1 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 1F12 unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 1-1037) antibodyHIP1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 1-1037) antibodyHIP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) antibodyHIP1 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 (HIP1) (AA 98-126), (N-Term) antibodyHIP1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- HIP1 (Huntingtin Interacting Protein 1 (HIP1))
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别名
- HIP1
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背景
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Synonyms: Huntingtin Interacting Protein HIP1, HIP I, HIP-1, HIP-I, hip1, HIP1/PDGFRB fusion gene, HIP1/PDGFRB fusion gene, included, HIP1_HUMAN, HIPI, Huntingtin interacting protein 1, Huntingtin-interacting protein 1, Huntingtin-interacting protein I, ILWEQ, KIAA4113, MGC126506, MGC27616, mKIAA4113.
Background: Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product huntingtin. HIP1 (huntingtin-interacting protein 1), a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels, and exhibits nearly identical subcellular fractionation as huntingtin. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking, the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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