DGCR6 抗体 (AA 112-180)
Quick Overview for DGCR6 抗体 (AA 112-180) (ABIN1387467)
抗原
See all DGCR6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 112-180
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预测反应
- Human,Mouse,Rat,Dog,Cow,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human DGCR6
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亚型
- IgG
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anti-DiGeorge Syndrome Critical Region Gene 6 (DGCR6) (AA 1-220) antibody
DGCR6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- DGCR6 (DiGeorge Syndrome Critical Region Gene 6 (DGCR6))
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别名
- DGCR6
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背景
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Synonyms: DGCR 6, DGCR6 protein, DiGeorge syndrome critical region 6, DiGeorge syndrome critical region gene 6, DGCR6_HUMAN.
Background: Neural crest cell migration to the third and fourth pharyngeal pouches is a critical step in the structural formation of organs that are affected in DiGeorge syndrome. DGCR6 (DiGeorge syndrome critical region 6) is a nuclear protein that plays a role in neural crest cell migration and is located at the DiGeorge syndrome critical region (DGCR) on chromosome 22. Expressed ubiquitously with highest levels in heart, liver and skeletal muscle, DGCR6 shares high homology with the Drosophila gonadal (gdl) protein and with human Laminin ?1, both of which are involved in early tissue development. The gene encoding DGCR6, along with other DGCR genes, is deleted in DiGeorge syndrome, a developmental disorder characterized by improper facial, cardiac and palate formation. Upregulation of DGCR6 is implicated in lung and colon adenocarcinomas, as well as in Burkitt_ lymphoma and lymphocytes transformed by EBV. Due to a duplication of the ancestral DGCR6 locus, there are two functional, highly homologous copies of the DGCR6 gene (designated DGCR6 and DGCR6L) on chromosome 22.
抗原
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