SHARPIN 抗体 (AA 260-310)
Quick Overview for SHARPIN 抗体 (AA 260-310) (ABIN1387105)
抗原
See all SHARPIN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 260-310
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SHARPIN
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亚型
- IgG
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anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 82-171) antibody
SHARPIN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-326) antibodySHARPIN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 51-148) antibodySHARPIN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 301-350) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-170) antibodySHARPIN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
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别名
- SHARPIN
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背景
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Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216
Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
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基因ID
- 81858
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UniProt
- Q9H0F6
抗原
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