RIT1 抗体 (AA 141-219)
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- 抗原 See all RIT1 抗体
- RIT1 (Ras-Like Without CAAX 1 (RIT1))
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抗原表位
- AA 141-219
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RIT1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human RIT1
- 亚型
- IgG
- Top Product
- Discover our top product RIT1 Primary Antibody
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anti-Ras-Like Without CAAX 1 (RIT1) (C-Term) antibody
RIT1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ras-Like Without CAAX 1 (RIT1) (AA 1-219) antibodyRIT1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ras-Like Without CAAX 1 (RIT1) (C-Term) antibodyRIT1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ras-Like Without CAAX 1 (RIT1) antibodyRIT1 适用: 人 WB 宿主: 小鼠 Monoclonal 14G7 unconjugated
anti-Ras-Like Without CAAX 1 (RIT1) (AA 120-217) antibodyRIT1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ras-Like Without CAAX 1 (RIT1) (C-Term) antibodyRIT1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- RIT1 (Ras-Like Without CAAX 1 (RIT1))
- 别名
- RIT1 (RIT1 产品)
- 背景
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Synonyms: GTP binding protein Roc1, GTP-binding protein Rit1, Ras like protein expressed in many tissues, Ras like without CAAX 1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1, RIBB, Ric like expressed in many tissues, RIT, RIT1, RIT1_HUMAN, ROC1.
Background: Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71 % and 66 % identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins
- 基因ID
- 6016
- 途径
- Neurotrophin Signaling Pathway
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