Nicalin 抗体 (AA 401-500)
Quick Overview for Nicalin 抗体 (AA 401-500) (ABIN1386554)
抗原
See all Nicalin (NCLN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 401-500
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Nicalin
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亚型
- IgG
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anti-Nicalin (NCLN) (AA 44-144) antibody
NCLN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nicalin (NCLN) (N-Term) antibodyNCLN 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nicalin (NCLN) (AA 214-522) antibodyNCLN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nicalin (NCLN) (C-Term) antibodyNCLN 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- Nicalin (NCLN)
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别名
- Nicalin/NCLN
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背景
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Synonyms: NCLN, NCLN_HUMAN, NET59, Nicalin, Nicalin homolog zebrafish, Nicastrin like protein, Nicastrin-like protein.
Background: Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.
抗原
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