LEFTY1 抗体 (AA 51-150)
Quick Overview for LEFTY1 抗体 (AA 51-150) (ABIN1386468)
抗原
See all LEFTY1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 51-150
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预测反应
- Human,Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Lefty
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亚型
- IgG
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anti-Left-Right Determination Factor 1 (LEFTY1) (AA 78-361) antibody
LEFTY1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E10 unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (Internal Region) antibodyLEFTY1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (N-Term) antibodyLEFTY1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 43-364) antibodyLEFTY1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 169-368) antibodyLEFTY1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 223-260) antibodyLEFTY1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Left-Right Determination Factor 1 (LEFTY1) (AA 1-366) antibodyLEFTY1 适用: 人 IP, ELISA 宿主: 小鼠 Monoclonal 4D7 unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))
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别名
- Lefty
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背景
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Synonyms: Protein lefty-1, AI450052, Ebaf, Left right determination factor 1, left right determination factor, Left right determination factor B, left-right determination factor, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTY1, left-right determination, factor B, LEFT-RIGHT DETERMINATION, FACTOR B, LEFTY B, LEFTB, LEFTY 1, Lefty, lefty-1, LEFTY1, LEFTY1, MOUSE, HOMOLOG OF antibody, LEFTYB, Protein lefty-B, RGD1561867, Stimulated by retinoic acid gene 3 protein, STRA3, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4.
Background: During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.
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基因ID
- 10637
抗原
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