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CXCL12 抗体 (AA 24-70)

Name: CXCL12 抗体 (AA 24-70)
SKU: ABIN1386329
Availability: OutOfStock

This anti-CXCL12 antibody is a 兔多克隆 antibody detecting CXCL12 in WB, ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 大鼠. This Primary Antibody has been cited in 3+ publications.

Formalin-fixed and paraffin embedded rat pancreas labeled with Anti-SDF-1/CXCL12 Polyclonal Antibody, Unconjugated (ABIN1386329) at 1:200 followed by conjugation to the secondary antibody and DAB staining (CXCL12 抗体 (AA 24-70))

IHC

1 image

(3 references)

产品编号 ABIN1386329

发货至: 中国

Datasheet as PDF

Quick Overview for CXCL12 抗体 (AA 24-70) (ABIN1386329)

抗原

See all CXCL12 抗体

CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

适用

大鼠

宿主

兔

克隆类型

多克隆

标记

This CXCL12 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product CXCL12 Primary Antibody

抗原表位
12

7

7

7

2

2

2

2

2

2

1

1

1

1
AA 24-70

交叉反应

大鼠

预测反应

Human,Mouse,Dog,Pig,Chicken,Guinea Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human SDF-1/CXCL12

亚型

IgG
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibody
CXCL12 适用: 人 WB, IHC, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 31-80) antibody
CXCL12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibody
CXCL12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人, 小鼠, 犬, 小鸡, 非洲爪蟾, Bat, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibody
CXCL12 适用: 人 WB 宿主: 小鼠 Monoclonal C3 unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人 WB, IHC, ELISA, IHC (p), Neut 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Wang, Chen, Tang, Jiang, Ji: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, (2016) (PubMed).

Grootaert, da Costa Martins, Bitsch, Pintelon, De Meyer, Martinet, Schrijvers: "Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis." in: Autophagy, (2015) (PubMed).

Pei, Zeng, Han, Liao, Zhou, Li, Zhang, Liu, Zhang, Liu, Yao, Xu: "Renal interstitial infiltration and tertiary lymphoid organ neogenesis in IgA nephropathy." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 9, Issue 2, pp. 255-64, (2014) (PubMed).
抗原

CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

别名

SDF1

背景

Synonyms: IRH, PBSF, SDF1, TLSF, TPAR1, SCYB12, Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, hIRH, Pre-B cell growth-stimulating factor, CXCL12, SDF1A, SDF1B
Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

基因ID

6387

UniProt

P48061

途径

Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling