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KLF1/2/4 抗体 (AA 279-303)

KLF1/2/4 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386255
发货至: 中国
  • 抗原 See all KLF1/2/4 products
    KLF1/2/4 (Kruppel-Like Factor 1/2/4 (KLF1/2/4))
    抗原表位
    AA 279-303
    适用
    人, 小鼠, 大鼠
    宿主
    • 14
    克隆类型
    • 14
    多克隆
    标记
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    • 1
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    This KLF1/2/4 antibody is un-conjugated
    应用范围
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human KLF1
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    KLF1/2/4 (Kruppel-Like Factor 1/2/4 (KLF1/2/4))
    Abstract
    KLF1/2/4 产品
    背景

    Synonyms: EKLF, INLU, CDAN4, HBFQTL6, Krueppel-like factor 1, Erythroid krueppel-like transcription factor, KLF1

    Background: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).

    基因ID
    10661
    UniProt
    Q13351
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