GABRG2 抗体 (pSer366)
Quick Overview for GABRG2 抗体 (pSer366) (ABIN1386210)
抗原
See all GABRG2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer366
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交叉反应
- 小鼠, 大鼠
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预测反应
- Human,Dog,Cow,Sheep,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human GABRG2 around the phosphorylation site of Ser366
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
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别名
- GABRG2
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背景
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Synonyms: p-GABAA R_2 Ser 365, CAE 2, CAE2, ECA 2, ECA2, GABAA receptor subunit gamma 2, GABAA receptor subunit gamma-2, GABRG 2, GABRG2 antibody Gamma aminobutyric acid GABA A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric-acid receptor gamma-2 subunit, GBRG2_HUMAN, GEFSP 3, GEFSP3.
Background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system, GABA functions as the main inhibitory transmitter by increasing a Cl- (chloride) conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors, as well as a third class of receptors called GABAC. The ?subunit of GABAA receptors are important for benzodiazepine binding and modulation of GABA-mediated Cl- current. GABAA R? is a 467 amino acid mulit-pass membrane protein localized to the postsynaptic cell membrane. Present as a pentamer with other GABAA receptor chains (Alpha, Beta, Gamma, Delta and Epsilon), the GABAA ligand-gated Cl- channels selectively complex with D5DR to enable mutual inhibitory functional interactions between the two receptor systems. Defects in the gene encoding GABAA R Gamma 2 have been found to be the cause of childhood absence epilepsy type 2, familial febrile convulsions type 8, generalized epilepsy with febrile seizures plus type 3 and severe myoclonic epilepsy in infancy.
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基因ID
- 2566
抗原
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