RGMB 抗体 (AA 58-160)
Quick Overview for RGMB 抗体 (AA 58-160) (ABIN1386086)
抗原
See all RGMB 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-160
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预测反应
- Human,Mouse,Rat,Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B
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亚型
- IgG
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anti-RGM Domain Family, Member B (RGMB) antibody
RGMB 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB56812 unconjugated
anti-RGM Domain Family, Member B (RGMB) (Center) antibodyRGMB 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RGM Domain Family, Member B (RGMB) (AA 376-406), (C-Term) antibodyRGMB 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RGM Domain Family, Member B (RGMB) (AA 210-453) antibodyRGMB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- RGMB (RGM Domain Family, Member B (RGMB))
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别名
- RGMB/Repulsive Guidance Molecule B
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背景
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Synonyms: Dragon, DRG11-responsive axonal guidance and outgrowth of neurite, Repulsive Guidance Molecule B, RGM b, RGM domain family member B, Rgmb, RGMB_HUMAN.
Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).
抗原
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