SRCAP 抗体 (AA 665-780)
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北京 101111
Quick Overview for SRCAP 抗体 (AA 665-780) (ABIN1386056)
抗原
See all SRCAP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 665-780
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预测反应
- Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human SRCAP
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亚型
- IgG
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anti-Snf2-Related CREBBP Activator Protein (SRCAP) (AA 309-322) antibody
Verified SRCAP 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Snf2-Related CREBBP Activator Protein (SRCAP) (Internal Region) antibodyVerified SRCAP 适用: 人 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- SRCAP (Snf2-Related CREBBP Activator Protein (SRCAP))
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别名
- SRCAP
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背景
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Synonyms: DOMO1, EAF1, Helicase SRCAP, Snf2 related CBP activator protein, SWR1, SRCAP_HUMAN.
Background: SRCAP (Snf2-related CREBBP activator protein), also known as EAF1, SWR1, or DOMO1, is a 3,230 amino acid protein that belongs to a family of helicases and contains one HSA domain, one helicase C-terminal domain, one helicase ATP-binding domain and three A.T hook DNA-binding domains. Localized to the nucleus, SRCAP functions as a catalytic component of the SRCAP complex, a multi-protein structure that mediates the ATP-dependent exchange of histone dimers for nucleosomal histones, an event that regulates the transcription of select genes via chromatin remodeling. Additionally, the SRCAP complex acts as a coactivator for steroid receptor-mediated transcription, Notch-mediated transcription and CREB-mediated transcription. SRCAP is expressed as multiple alternatively spliced isoforms and is subject to DNA damage-dependent phosphorylation by ATM or ATR.
抗原
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