IGF2BP1 抗体 (AA 31-130)
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北京 101111
Quick Overview for IGF2BP1 抗体 (AA 31-130) (ABIN1386018)
抗原
See all IGF2BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-130
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Zebrafish
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human IGF2BP1/IMP1
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亚型
- IgG
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anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (C-Term) antibody
IGF2BP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (AA 508-534), (C-Term) antibodyIGF2BP1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21526 unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (N-Term) antibodyIGF2BP1 适用: 人, 小鼠, 大鼠, 兔, 犬, Cow, 马, 豚鼠, Pig, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (AA 440-534) antibodyIGF2BP1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) antibodyIGF2BP1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB170 unconjugated Recombinant Antibody
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (Internal Region) antibodyVerified IGF2BP1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (N-Term) antibodyIGF2BP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (AA 155-204) antibodyIGF2BP1 适用: 人, 大鼠, 兔, 犬, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) (AA 515-542), (C-Term) antibodyIGF2BP1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1) antibodyIGF2BP1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- IGF2BP1 (Insulin-Like Growth Factor 2 mRNA Binding Protein 1 (IGF2BP1))
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别名
- IGF2BP1
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背景
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Synonyms: IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1, Insulin-like growth factor 2 mRNA-binding protein 1, IGF2 mRNA-binding protein 1, Coding region determinant-binding protein, IGF-II mRNA-binding protein 1, VICKZ family member 1, Zipcode-binding protein 1, ZBP-1, IGF2BP1
Background: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation.
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基因ID
- 10642
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UniProt
- Q9NZI8
抗原
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