电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

CHN1 抗体 (AA 151-250)

ARHGAP2 适用: 人 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1385870
发货至: 中国
  • 抗原 See all CHN1 (ARHGAP2) 抗体
    CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))
    抗原表位
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    适用
    • 34
    • 9
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    宿主
    • 25
    • 9
    克隆类型
    • 27
    • 7
    多克隆
    标记
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    This CHN1 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    预测反应
    Human,Mouse,Rat,Dog,Cow,Sheep,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Alpha-chimerin
    亚型
    IgG
    Top Product
    Discover our top product ARHGAP2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))
    别名
    CHN 1/Alpha-chimerin (ARHGAP2 产品)
    别名
    ARHGAP2 antibody, CHN antibody, DURS2 antibody, NC antibody, RHOGAP2 antibody, 0610007I19Rik antibody, 0710001E19Rik antibody, 1700112L09Rik antibody, 2900046J01Rik antibody, AI413815 antibody, chimaerin antibody, wu:fr89a09 antibody, zgc:56160 antibody, zgc:92906 antibody, N-chimaerin antibody, chimerin 1 antibody, chimerin 1 L homeolog antibody, CHN1 antibody, Chn1 antibody, chn1.L antibody, chn1 antibody
    背景

    Synonyms: A-chimaerin, Alpha-chimerin, ARHGAP2, CHIN_HUMAN, CHN, Chn1, N chimaerin, N chimerin, N-chimaerin, N-chimerin, NC, Rho GTPase-activating protein 2, RHOGAP2.

    Background: The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.

You are here:
客服