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FOXC2 抗体

FOXC2 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1385810
发货至: 中国
  • 抗原 See all FOXC2 抗体
    FOXC2 (Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2))
    适用
    • 50
    • 13
    • 10
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 39
    • 10
    • 1
    • 1
    克隆类型
    • 40
    • 11
    多克隆
    标记
    • 32
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FOXC2 antibody is un-conjugated
    应用范围
    • 36
    • 28
    • 16
    • 9
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human FOX C2
    亚型
    IgG
    Top Product
    Discover our top product FOXC2 Primary Antibody
  • 应用备注
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    FOXC2 (Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2))
    别名
    FOX C2 (FOXC2 产品)
    背景

    Synonyms: Drosphilia Forkhead Homolog Like 14, Drosphilia Forkhead Homolog Like 14, FKHL 14, FKHL 14, FKHL14, Forkhead Box C2, Forkhead Box C2, Forkhead box protein C2, Forkhead related protein FKHL14, Forkhead-related protein FKHL14, FOX C2, Foxc2, FOXC2_HUMAN, LD, Mesenchyme fork head protein 1, Mesenchyme Forkhead 1, Mesenchyme Forkhead 1, MFH 1, MFH 1, MFH 1 protein, MFH-1 protein, MFH1, Transcription factor FKH 14, Transcription factor FKH-14.

    Background: FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3). FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4). Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4). FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3). FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3). FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2).

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