FOXC2 抗体
Quick Overview for FOXC2 抗体 (ABIN1385810)
抗原
See all FOXC2 抗体适用
宿主
克隆类型
标记
应用范围
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human FOX C2
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亚型
- IgG
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anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (C-Term) antibody
Verified FOXC2 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 156-256) antibodyFOXC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 421-501) antibodyFOXC2 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2H3 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 156-256) antibodyFOXC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 421-501) antibodyFOXC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B3 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 156-256) antibodyFOXC2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D4 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 21-210) antibodyFOXC2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1D11C8 unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 24-294) antibodyFOXC2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 51-100) antibodyFOXC2 适用: 人, 小鼠, 大鼠, Cow, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2) (AA 159-186) antibodyFOXC2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20052 unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- FOXC2 (Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2))
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别名
- FOX C2
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背景
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Synonyms: Drosphilia Forkhead Homolog Like 14, Drosphilia Forkhead Homolog Like 14, FKHL 14, FKHL 14, FKHL14, Forkhead Box C2, Forkhead Box C2, Forkhead box protein C2, Forkhead related protein FKHL14, Forkhead-related protein FKHL14, FOX C2, Foxc2, FOXC2_HUMAN, LD, Mesenchyme fork head protein 1, Mesenchyme Forkhead 1, Mesenchyme Forkhead 1, MFH 1, MFH 1, MFH 1 protein, MFH-1 protein, MFH1, Transcription factor FKH 14, Transcription factor FKH-14.
Background: FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3). FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4). Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4). FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3). FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3). FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2).
抗原
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