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SH3RF1 抗体

This anti-SH3RF1 antibody is a 兔 多克隆 antibody detecting SH3RF1 in WB, IF (p) 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN1385771
发货至: 中国

Quick Overview for SH3RF1 抗体 (ABIN1385771)

抗原

See all SH3RF1 抗体
SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This SH3RF1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human SH3MD2/RNF142

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))

    别名

    RNF142

    背景

    Synonyms: Plenty of SH3 domains, Plenty of SH3s, POSH, Ring finger protein 142, RNF 142, RNF142, SH3 domain containing ring finger 1, SH3 domain containing RING finger protein 1, SH3MD2, SH3 multiple domains 2, SH3RF1.

    Background: SH3MD2 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3MD2 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane. This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. There are two named isoforms.

    基因ID

    57630
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