NOS1AP 抗体 (AA 128-170)
Quick Overview for NOS1AP 抗体 (AA 128-170) (ABIN1385736)
抗原
See all NOS1AP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 128-170
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预测反应
- Human,Mouse,Rat,Cow,Sheep,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human CAPON
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亚型
- IgG
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anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) antibody
NOS1AP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 285-506) antibodyNOS1AP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 19-251) antibodyNOS1AP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 176-288), (C-Term) antibodyNOS1AP 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (N-Term) antibodyVerified NOS1AP 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 1-506) antibodyNOS1AP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 1-506) antibodyNOS1AP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 99-202) antibodyNOS1AP 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3B11 unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 437-466) antibodyNOS1AP 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB27629 unconjugated
anti-Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP) (AA 444-474), (Middle Region) antibodyNOS1AP 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))
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别名
- CAPON
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背景
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Synonyms: NOS1AP, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 neuronal adaptor protein, Nitric oxide synthase 1 adaptor protein.
Background: CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.
抗原
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