CLEC11A 抗体
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- 抗原 See all CLEC11A 抗体
- CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CLEC11A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Pleckstrin/p47
- 亚型
- IgG
- Top Product
- Discover our top product CLEC11A Primary Antibody
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- CLEC11A (C-Type Lectin Domain Family 11, Member A (CLEC11A))
- 别名
- p47 (CLEC11A 产品)
- 别名
- CLEC11A antibody, CLECSF3 antibody, LSLCL antibody, P47 antibody, SCGF antibody, AW457320 antibody, Clecsf3 antibody, Scgf antibody, C-type lectin domain containing 11A antibody, C-type lectin domain family 11, member a antibody, CLEC11A antibody, Clec11a antibody
- 背景
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Synonyms: p47, Platelet 47 kDa protein, Platelet and leukocyte C kinase substrate, Platelet P47, Platelet p47 protein, Pleckstrin, PLEK, PLEK_HUMAN, FLJ27168, OTTHUMP00000159962.
Background: Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89 % sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
- 基因ID
- 5341
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