CD86 抗体
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北京 101111
Quick Overview for CD86 抗体 (ABIN135277)
抗原
See all CD86 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Rat Anti-Mouse CD86-LE/AF
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特异性
- Mouse CD86, Mr 80 kDa
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产品特性
- Low Endotoxin/Azide Free Anti-Mouse CD86 antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.
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内毒素水平
- Low Endotoxin
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免疫原
- LPS-activated CBA/Ca mouse spleen B cells
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- CD86
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别名
- CD86
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背景
- CD86, also known as B7-2, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B-cell specific stimuli with peak expression at 18-42 hours after stimulation. CD86, along with CD80/B7-1, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA-4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response.
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基因ID
- 12524
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UniProt
- P42082
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
抗原
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