Transferrin Receptor 抗体
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北京 101111
Quick Overview for Transferrin Receptor 抗体 (ABIN135259)
抗原
See all Transferrin Receptor (TFRC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Mouse CD71, Mr 95 kDa
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产品特性
- Rat Anti-Mouse CD71-UNLB
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纯化方法
- Purified
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免疫原
- DMSO induced Friend erythroleukemia 745.6
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亚型
- IgG2a
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应用备注
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- Applications: FC - Quality tested , ICC - Reported in literature , IP - Reported in literature , WB - Reported in literature , Block - Reported in literature , Sep - Reported in literature , Drug Delivery - Reported in literature
- Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
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样本量
- 1 mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
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储存液
- Without preservative
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C
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: "Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer." in: PLoS ONE, Vol. 7, Issue 2, pp. e31070, (2012) (PubMed).
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: "Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer." in: PLoS ONE, Vol. 7, Issue 2, pp. e31070, (2012) (PubMed).
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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别名
- CD71
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背景
- CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor chain.
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途径
- Transition Metal Ion Homeostasis
抗原
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