CD32/CD16 抗体
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北京 101111
Quick Overview for CD32/CD16 抗体 (ABIN135200)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Rat Anti-Mouse CD16/32-LE/AF
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特异性
- Mouse CD16/32
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产品特性
- Low Endotoxin/Azide Free Anti-Mouse CD16/32 antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.
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内毒素水平
- Low Endotoxin
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免疫原
- VH81X Tg B cells and T220 stromal cell line
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- CD32/CD16
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别名
- CD16/32
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背景
- The lymphocyte Fc receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fc type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression.4 Besides identifying FcR+ cells, monoclonal antibodies to the FcII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcR for parasitic invasion.
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基因ID
- 14131
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UniProt
- P08508
抗原
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