CD22 抗体
Our Local Distributor
北京 101111
Quick Overview for CD22 抗体 (ABIN135163)
抗原
See all CD22 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Rat Anti-Mouse CD22-LE/AF
-
特异性
- Mouse CD22, Mr 150 kDa
-
产品特性
- Low Endotoxin/Azide Free Anti-Mouse CD22 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.
-
内毒素水平
- Low Endotoxin
-
免疫原
- Splenic lymphocyte plasma membranes from CBA x C57 F1 mice
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Phosphate buffered saline, pH 7.4
-
储存液
- Azide free
-
注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
-
储存条件
- 4 °C
-
储存方法
- 2-8°C
-
-
- CD22 (CD22 Molecule (CD22))
-
别名
- CD22
-
背景
- CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.
-
基因ID
- 12483
-
UniProt
- P35329
抗原
-