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CD22 抗体

This 大鼠 单克隆 antibody specifically detects CD22 in FACS, IP, ICC, IHC (p), IHC (fro) 和 Act. It exhibits reactivity toward 小鼠.
产品编号 ABIN135163
发货至: 中国
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Our Local Distributor

中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for CD22 抗体 (ABIN135163)

抗原

See all CD22 抗体
CD22 (CD22 Molecule (CD22))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This CD22 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Activation (Act)

克隆位点

2D6
  • 原理

    Rat Anti-Mouse CD22-LE/AF

    特异性

    Mouse CD22, Mr 150 kDa

    产品特性

    Low Endotoxin/Azide Free Anti-Mouse CD22 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.

    内毒素水平

    Low Endotoxin

    免疫原

    Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    Phosphate buffered saline, pH 7.4

    储存液

    Azide free

    注意事项

    Each reagent is stable for the period shown on the bottle label if stored as directed.

    储存条件

    4 °C

    储存方法

    2-8°C
  • 抗原

    CD22 (CD22 Molecule (CD22))

    别名

    CD22

    背景

    CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.

    基因ID

    12483

    UniProt

    P35329
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