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CD22 抗体

This anti-CD22 antibody is a 大鼠 单克隆 antibody detecting CD22 in FACS. Suitable for 小鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN135158
发货至: 中国

Quick Overview for CD22 抗体 (ABIN135158)

抗原

See all CD22 抗体
CD22 (CD22 Molecule (CD22))

适用

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小鼠

宿主

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大鼠

克隆类型

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  • 1
单克隆

标记

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This CD22 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS)

克隆位点

2D6
  • 特异性

    Mouse CD22, Mr 150 kDa

    产品特性

    Rat Anti-Mouse CD22-UNLB

    纯化方法

    Purified

    免疫原

    Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

    亚型

    IgG1
  • 应用备注

    • Applications: FC - Quality tested , IHC-FS - Reported in literature , IHC-PS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Activ - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE, APC, and SPRD conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

    样本量

    1 mL

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

    储存液

    Without preservative

    注意事项

    Each reagent is stable for the period shown on the bottle label if stored as directed.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C
  • Kreimann, Jang, Rong, Greite, von Vietinghoff, Schmitt, Bräsen, Schiffer, Gerstenberg, Vijayan, Dittrich-Breiholz, Wang, Karsten, Gwinner, Haller, Immenschuh, Gueler: "Ischemia Reperfusion Injury Triggers CXCL13 Release and B-Cell Recruitment After Allogenic Kidney Transplantation." in: Frontiers in immunology, Vol. 11, pp. 1204, (2020) (PubMed).

  • 抗原

    CD22 (CD22 Molecule (CD22))

    别名

    CD22

    背景

    CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.
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