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ITGA4 抗体

This 大鼠 单克隆 antibody specifically detects ITGA4 in FACS, IP, IHC (fro), BR 和 Adh Act. It exhibits reactivity toward 人 和 小鼠.
产品编号 ABIN135079
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for ITGA4 抗体 (ABIN135079)

抗原

See all ITGA4 抗体
ITGA4 (Integrin alpha 4 (ITGA4))

适用

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人, 小鼠

宿主

  • 78
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大鼠

克隆类型

  • 126
  • 59
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单克隆

标记

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This ITGA4 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Adhesion Activation (Adh Act)

克隆位点

PS-2
  • 原理

    Rat Anti-Mouse CD49d-LE/AF

    特异性

    Mouse/Human CD49d, Mr 150 kDa

    产品特性

    Low Endotoxin/Azide Free Anti-Mouse CD49d antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and adhesion assays.

    内毒素水平

    Low Endotoxin

    免疫原

    P815 cells

    亚型

    IgG2b
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    Phosphate buffered saline, pH 7.4

    储存液

    Azide free

    注意事项

    Each reagent is stable for the period shown on the bottle label if stored as directed.

    储存条件

    4 °C

    储存方法

    2-8°C
  • 抗原

    ITGA4 (Integrin alpha 4 (ITGA4))

    别名

    CD49d

    背景

    CD49d, the 4 chain (100 kDa) of the VLA-4 integrin heterodimer (Mr 150 kDa) VLA-4 belongs to the 1-integrin family, which functions both as cell-matrix and cell-cell receptors.1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.

    基因ID

    16401

    UniProt

    Q00651

    途径

    Integrin Complex
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