ITGA4 抗体
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北京 101111
Quick Overview for ITGA4 抗体 (ABIN135079)
抗原
See all ITGA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Rat Anti-Mouse CD49d-LE/AF
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特异性
- Mouse/Human CD49d, Mr 150 kDa
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产品特性
- Low Endotoxin/Azide Free Anti-Mouse CD49d antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and adhesion assays.
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内毒素水平
- Low Endotoxin
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免疫原
- P815 cells
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亚型
- IgG2b
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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注意事项
- Each reagent is stable for the period shown on the bottle label if stored as directed.
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- ITGA4 (Integrin alpha 4 (ITGA4))
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别名
- CD49d
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背景
- CD49d, the 4 chain (100 kDa) of the VLA-4 integrin heterodimer (Mr 150 kDa) VLA-4 belongs to the 1-integrin family, which functions both as cell-matrix and cell-cell receptors.1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.
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基因ID
- 16401
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UniProt
- Q00651
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途径
- Integrin Complex
抗原
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