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VCAM1 抗体

There are 2+ publications for this product available. The 大鼠 单克隆 anti-VCAM1 antibody is suitable to detect VCAM1 in samples from 小鼠. It has been validated for WB, FACS, IP, IHC (fro), BR 和 Adh Act.
产品编号 ABIN135074
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for VCAM1 抗体 (ABIN135074)

抗原

See all VCAM1 抗体
VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

适用

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小鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This VCAM1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Adhesion Activation (Adh Act)

克隆位点

M-K-2
  • 原理

    Rat Anti-Mouse CD106-LE/AF

    特异性

    Mouse CD106, Mr 100-110 kDa

    产品特性

    Low Endotoxin/Azide Free Anti-Mouse CD106 antibody for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, blocking, and adhesion assays.

    内毒素水平

    Low Endotoxin

    免疫原

    BALB/3T3 and +/+2.4 cells

    亚型

    IgG1
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.5 mg/mL

    缓冲液

    Phosphate buffered saline, pH 7.4

    储存液

    Azide free

    注意事项

    Each reagent is stable for the period shown on the bottle label if stored as directed.

    储存条件

    4 °C

    储存方法

    2-8°C
  • Gilchrist, Kinchesh, Zarghami, Khrapitchev, Sibson, Kersemans, Smart: "Improved detection of molecularly targeted iron oxide particles in mouse brain using B0 field stabilised high resolution MRI." in: Magnetic resonance imaging, Vol. 67, pp. 101-108, (2020) (PubMed).

    Zarghami, Khrapitchev, Perez-Balderas, Soto, Larkin, Bau, Sibson: "Optimization of molecularly targeted MRI in the brain: empirical comparison of sequences and particles." in: International journal of nanomedicine, Vol. 13, pp. 4345-4359, (2018) (PubMed).

  • 抗原

    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

    别名

    CD106

    背景

    VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein.

    基因ID

    22329

    UniProt

    P29533

    途径

    Carbohydrate Homeostasis
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