SHANK1 抗体 (AA 469-691)
Quick Overview for SHANK1 抗体 (AA 469-691) (ABIN1304952)
抗原
See all SHANK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 469-691
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特异性
- No off-targets reported for Shank2 or Shank3
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
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Description: Our Anti-Shank1 mouse monoclonal primary antibody is produced in-house from hybridoma clone N22/21. It detects human, mouse, and rat Shank1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Manufacturer Comment: We produce our Shank1 mouse monoclonal primary antibody from hybridoma clone N22/21. It is great in IHC, ICC, WB and is purified by Protein A chromatography.
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纯化方法
- Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.
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纯度
- > 90% specific antibody
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免疫原
- Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48) produced recombinantly in E. Coli
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亚型
- IgG1
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anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody
SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) unconjugated
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (HRP)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) HRP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (FITC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) FITC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Biotin)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Biotin
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (PE)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) PE
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (APC)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) APC
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (PerCP)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) PerCP
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 488)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 488
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 594)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 594
anti-SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1) (AA 469-691) antibody (Atto 390)SHANK1 适用: 大鼠 WB, IHC, AA 宿主: 小鼠 Monoclonal N22-21 (Formerly S22-21) Atto 390
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应用备注
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Dilution Range: ICC: 1:400
Dilution Range: WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
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有效期
- 24 months
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- SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1 (SHANK1))
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别名
- Shank1
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背景
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Synonyms: SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)
Target Description: SH3 and multiple ankyrin repeat domains protein 1, or shank 1 is a member of the shank family. Shank 1 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Unlike other shank family proteins, shank 1 is found in only in brain in the neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum, amygdala, substantia nigra and thalamus. Cellularly, shank 1 can be found in cytoplasm, cell junctions, postsynaptic cell membrane and postsynaptic density. Many isoforms of shank 1 exist, and some are expressed during development, while others are expressed in mature tissue. Shank 1 acts as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 1 may play a role in synapse formation and dendritic spine maturation. Mutations in this gene have been associated with autism spectrm disorder and diabetic encephalopathy.
Gene Name Alternatives: Shank1
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分子量
- 190-220 kDa (alternative splice variants)
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UniProt
- Q9WV48
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途径
- Synaptic Membrane, Maintenance of Protein Location
抗原
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