HCN4 抗体 (AA 1019-1108)
Quick Overview for HCN4 抗体 (AA 1019-1108) (ABIN1304702)
抗原
See all HCN4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1019-1108
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特异性
- No off-targets reported for other HCN's
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交叉反应
- Gerbil, 人, 小鼠, Pig, 大鼠
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产品特性
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Description: Our Anti-HCN4 mouse monoclonal primary antibody is produced in-house from hybridoma clone N114/10. It detects human, mouse, and rat HCN4, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Manufacturer Comment: We produce our HCN4 mouse monoclonal primary antibody from hybridoma clone N114/10. It is great in IHC, ICC, WB and is purified by Protein A chromatography.
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纯化方法
- Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.
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纯度
- > 90% specific antibody
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免疫原
- Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (accession number Q9JKA7) produced recombinantly in E. Coli
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亚型
- IgG1
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应用备注
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Dilution Range: IHC: 1:200
Dilution Range: ICC: 1:200
Dilution Range: WB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4
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储存条件
- 4 °C,-20 °C
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储存方法
- Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
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有效期
- 24 months
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- HCN4 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4))
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别名
- HCN4
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背景
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Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Target Description: HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.
Gene Name Alternatives: HCN4
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分子量
- 130 kDa
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UniProt
- Q9JKA7
抗原
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