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GRIA2 抗体 (AA 834-883)

This anti-GRIA2 antibody is a 小鼠 单克隆 antibody detecting GRIA2 in WB, IHC, IP, ICC 和 IEM. Suitable for 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN1304677
发货至: 中国

Quick Overview for GRIA2 抗体 (AA 834-883) (ABIN1304677)

抗原

See all GRIA2 抗体
GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

适用

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大鼠

宿主

  • 92
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小鼠

克隆类型

  • 80
  • 38
单克隆

标记

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This GRIA2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunoelectron Microscopy (IEM)

克隆位点

L21-32
  • 抗原表位

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    AA 834-883

    特异性

    No off-targets reported for GluA1/GluR1, GluA3/GluR3 or GluA4/GluR4 (based on KO validation results)

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Description: Our Anti-GluA2/GluR2 glutamate receptor mouse monoclonal primary antibody is produced in-house from hybridoma clone L21/32. It is KO validated, detects human, mouse, and rat GluA2/GluR2 glutamate receptor, and is purified by Protein A chromatography. It is great for use in EM, IHC, ICC, IP, WB.

    Manufacturer Comment: We produce our GluA2/GluR2 glutamate receptor mouse monoclonal primary antibody from hybridoma clone L21/32. It is great in EM, IHC, ICC, IP, WB and is purified by Protein A chromatography.

    纯化方法

    Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

    纯度

    > 90% specific antibody

    免疫原

    Fusion protein amino acids 834-883 (EFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI, cytoplasmic C-terminus) of rat GluA2/GluR2 produced recombinantly in E. Coli

    亚型

    IgG1
  • 应用备注

    Dilution Range: IHC: 1:250

    Dilution Range: ICC: 1:500

    Dilution Range: WB: 1:500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

    储存条件

    4 °C,-20 °C

    储存方法

    Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

    有效期

    24 months
  • Gonzalez-Lozano, Klemmer, Gebuis, Hassan, van Nierop, van Kesteren, Smit, Li: "Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development." in: Scientific reports, Vol. 6, pp. 35456, (2016) (PubMed).

  • 抗原

    GRIA2 (Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2))

    别名

    GluR2 glutamate receptor

    背景

    Synonyms: Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (GluA2)

    Target Description: Glutelin type-A 2 (GluA2) , also called GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2 or glutamate ionotropic receptor AMPA type subunit 2, is a member of the Glutamate receptor family of the mammalian brain. This neurotransmiter receptor subunit, which is activated during normal central nervous system fuction, is encoded by the GRIA2 (or GLUR2) gene. GluA2 constitutes a key subunit that regulates AMPA receptors. AMPA receptors lacking of Glua2 have been shown to be present in diseased brains, whose basic fuctions have been altered.

    Gene Name Alternatives: Gria2 Glur2

    分子量

    90 kDa

    UniProt

    P19491

    途径

    PI3K-Akt Signaling
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