SCIMP 抗体
This anti-SCIMP antibody is a 小鼠 单克隆 antibody detecting SCIMP in IP, WB, ICC 和 ICFC. Suitable for 人. This Primary Antibody has been cited in 1 publication.
(1 reference)Quick Overview for SCIMP 抗体 (ABIN1302508)
抗原
See all SCIMP 抗体
SCIMP
(SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This SCIMP antibody is un-conjugated
应用范围
Immunoprecipitation (IP), Western Blotting (WB), Immunocytochemistry (ICC), Intracellular Flow Cytometry (ICFC)
克隆位点
NVL-07
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原理
- Anti-SCIMP Purified
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特异性
- The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Recombinant intracellular part of human SCIMP
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亚型
- IgG2a
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anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) antibody (PE)
SCIMP 适用: 人 ICFC 宿主: 小鼠 Monoclonal NVL-07 PE
anti-SLP Adaptor and CSK Interacting Membrane Protein (SCIMP) (AA 59-145) antibodySCIMP 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow cytometry: Recommended dilution: 1-5 μg/mL. Intracellular staining.
Western blotting: Recommended dilution: 1-2 μg/mL. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling." in: Molecular and cellular biology, Vol. 31, Issue 22, pp. 4550-62, (2011) (PubMed).
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: "SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling." in: Molecular and cellular biology, Vol. 31, Issue 22, pp. 4550-62, (2011) (PubMed).
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- SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
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别名
- SCIMP
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背景
- SLP adaptor and CSK interacting membrane protein,SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.,NVL
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基因ID
- 388325
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UniProt
- Q6UWF3
抗原
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