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Selectin E/CD62e 抗体

This anti-Selectin E/CD62e antibody is a 兔 多克隆 antibody detecting Selectin E/CD62e in WB, IP 和 IHC (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN127258
发货至: 中国

Quick Overview for Selectin E/CD62e 抗体 (ABIN127258)

抗原

See all Selectin E/CD62e (SELE) 抗体
Selectin E/CD62e (SELE) (Selectin E (SELE))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Selectin E/CD62e antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 纯化方法

    Protein A Affinity Chromatography

    免疫原

    Synthetic peptide surrounding amino acid 584 of Human E-Selectin.

    亚型

    IgG
  • 应用备注

    Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 10-20 μg/mL. Immunohistochemistry (Paraffin Sections): 10-20 μg/mL. Positive Controls: Jurkat cell lysate, Mouse small intestine and Rat kidney tissue lysate.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.5 mg/mL

    缓冲液

    PBS containing 0.02 % Thimerosal as preservative

    储存液

    Thimerosal (Merthiolate)

    注意事项

    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C/-80 °C

    储存方法

    Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -20 °C to -70 °C.
  • 抗原

    Selectin E/CD62e (SELE) (Selectin E (SELE))

    别名

    CD62E / E-Selectin

    背景

    Selectin E is also known as endothelial leukocyte adhesion molecule 1 (ELAM1) or CD62E. It is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. CD62E (E selectin) is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. CD62E has been associated with blood vessel endothelium in diverse inflammatory situations. The main ligands recognised by CD62E are oligosaccharides related to sialyl lewis x.Synonyms: CD62 antigen-like family member E, ELAM1, Endothelial leukocyte adhesion molecule 1, LECAM2, Leukocyte-endothelial cell adhesion molecule 2, SELE

    基因ID

    9606

    UniProt

    P16581

    途径

    Thromboxane A2 Receptor Signaling
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