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LCK 抗体 (C-Term)

Name: LCK 抗体 (C-Term)
SKU: ABIN127163
Availability: OutOfStock

This anti-LCK antibody is a 兔多克隆 antibody detecting LCK in WB, IP 和 IHC (p). Suitable for 人, 小鼠, 大鼠和小鸡.

Image no. 1 for anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (C-Term) antibody (ABIN127163) (LCK 抗体 (C-Term))

1 image

产品编号 ABIN127163

发货至: 中国

Quick Overview for LCK 抗体 (C-Term) (ABIN127163)

抗原

See all LCK 抗体

LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

适用

人, 小鼠, 大鼠, 小鸡

宿主

兔

克隆类型

多克隆

标记

This LCK antibody is un-conjugated

应用范围

Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product LCK Primary Antibody

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C-Term

特异性

The antibody detects 56 kDa Lck protein.

纯化方法

Antigen affinity purified

免疫原

Synthetic peptide corresponding to the C-terminus of human Lck
anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-539) antibody
LCK 适用: 人 WB, ELISA, IP, RNAi 宿主: 小鼠 Monoclonal 3F7-F5 unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-240) antibody
LCK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 22-36) antibody
LCK 适用: 人 WB, IP, ICC, ICFC 宿主: 小鼠 Monoclonal LCK-01 unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 23-52) antibody
LCK 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-539) antibody
LCK 适用: 人 ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 468-506), (C-Term) antibody
LCK 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 480-509) antibody
LCK 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 421-509) antibody
LCK 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 39-52) antibody
Verified LCK 适用: 人, 大鼠, Pig WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Lymphocyte-Specific Protein tyrosine Kinase (LCK) (AA 1-539) antibody
LCK 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

应用备注

Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 20-25 μg/mL. Immunohistochemistry: 20-25 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

0.5 mg/mL

缓冲液

PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal

储存液

Thimerosal (Merthiolate)

注意事项

This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C/-80 °C

储存方法

Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
抗原

LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

别名

LCK

背景

Lck is a lymphoid specific cytosolic protein tyrosine kinase (PTK), which is essential for T cell development and function. It is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T cell antigen receptor (TCR) linked signal transduction pathways. Association of the TCR with a peptide antigen bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated Lck to the vicinity of the TCR/CD3 complex. Lck then phosphorylates tyrosine residues within the immunoreceptor tyrosine based activation motifs (ITAMs) in the cytoplasmic tails of the TCR chains and CD3 subunits. The phosphoITAMs serve as docking sites for Src homology domain 2 (SH2) containing molecules, predominantly ZAP 70 and Syk. Only then can ZAP 70 undergo tyrosine phosphorylation, become enzymatically active and further phosphorylate downstream effector molecules. In addition, Lck contributes to signaling by other receptor molecules. Lck is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature TCR.Synonyms: LSK, Lymphocyte cell-specific protein-tyrosine kinase, Proto-oncogene tyrosine-protein kinase LCK, T cell-specific protein-tyrosine kinase, p56-LCK

基因ID

3932

NCBI登录号

NP_001036236

UniProt

P06239

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling