Cathepsin L 抗体
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北京 101111
Quick Overview for Cathepsin L 抗体 (ABIN127049)
抗原
See all Cathepsin L (CTSL1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Detects both the proenzyme and the mature form of cathepsin L.
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纯化方法
- Affinity purified
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免疫原
- Synthetic peptide surrounding amino acid 223 of human Cathepsin L
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应用备注
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Western Blot: 0.5-4 μg/mL, Jurkat cell lysate can be used as a positive control.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -20 °C to -70 °C.
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- Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))
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别名
- Cathepsin L1
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背景
- Cathepsin L is a normal lysosomal cysteine endoproteases that is expressed in all cells. The latent 39 kDa pro-Cathepsin L must be processed by cleavage of the 96 amino acid propeptide, to generate the active two-chain form made up of 21 and 5 kDa subunits. Mature Cathepsin L is normally localized in the lysosomes where it plays a major role in intracellular protein catabolism. The fact that Cathepsin L is also capable of degrading extracellular matrix proteins suggests that it may play a role in invation and metastasis and could be a useful prognostic indicator for cancer.Synonyms: CTSL, CTSL1, Cathepsin-L1, MEP, Major excreted protein
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基因ID
- 1514
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NCBI登录号
- NP_001903
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UniProt
- P07711
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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