HRK 抗体
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北京 101111
Quick Overview for HRK 抗体 (ABIN127035)
抗原
See all HRK 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- The antibody detects Hrk fused with green fluorescent protein in crude extracts of E. coli transfected with Hrk-GFP.
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纯化方法
- Affinity purified
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免疫原
- Synthetic peptide corresponding to residues surrounding amino acids 50 of human HRK.
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anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) antibody
HRK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (Center) antibodyHRK 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (AA 1-50) antibodyHRK 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (N-Term) antibodyHRK 适用: 人, Cow, 犬, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (AA 15-50) antibodyHRK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB04688 unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (N-Term) antibodyHRK 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK) (BH3 Domain) antibodyHRK 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
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- HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))
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别名
- Harakiri / HRK
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背景
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3) group of the Bcl-2 family of proteins, was identified as a novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5
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基因ID
- 8739
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NCBI登录号
- NP_003797
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UniProt
- O00198
抗原
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