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Calreticulin 抗体 (C-Term)

This anti-Calreticulin antibody is a 兔 多克隆 antibody detecting Calreticulin in WB 和 IHC (p). Suitable for 人, 小鼠, 大鼠 和 猴.
产品编号 ABIN126998
发货至: 中国

Quick Overview for Calreticulin 抗体 (C-Term) (ABIN126998)

抗原

See all Calreticulin (CALR) 抗体
Calreticulin (CALR)

适用

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人, 小鼠, 大鼠, 猴

宿主

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克隆类型

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多克隆

标记

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This Calreticulin antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    C-Term

    特异性

    Recognizes a 60 kDa calreticulin on SDS-PAGE immunoblots.

    纯化方法

    Protein A purified

    免疫原

    Synthetic peptide from the C-terminus of Human Calreticulin
  • 应用备注

    Western blot: 0.5-2 μg/mL. Immunohistochemistry. NIH/3T3 cell lysate can be used as a positive control.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    0.2 mg/mL

    缓冲液

    PBS containing 1 mg/mL BSA, 1.5 mM sodium azide and 50 % glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C/-80 °C

    储存方法

    Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
  • 抗原

    Calreticulin (CALR)

    别名

    Calreticulin

    背景

    Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies suggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also suggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.Synonyms: CALR, CRP55, CRTC, Calregulin, ERp60, HACBP, grp60

    基因ID

    811

    NCBI登录号

    NP_004334

    UniProt

    P27797

    途径

    Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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