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beta Amyloid 抗体 (C-Term)

Abeta 适用: 人 WB, IF, EIA 宿主: 小鼠 Monoclonal 9F1 unconjugated
产品编号 ABIN126722
发货至: 中国
  • 抗原 See all beta Amyloid (Abeta) 抗体
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    抗原表位
    • 18
    • 18
    • 11
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 70
    • 22
    • 15
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 42
    • 26
    • 3
    • 2
    小鼠
    克隆类型
    • 38
    • 29
    • 1
    单克隆
    标记
    • 63
    • 5
    • 2
    • 1
    • 1
    • 1
    This beta Amyloid antibody is un-conjugated
    应用范围
    • 53
    • 50
    • 29
    • 17
    • 15
    • 13
    • 9
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    This antibody interacts with the C-termini of both beta-Amyloid (1-40) and (1-42).
    纯化方法
    Size Exclusion Chromatography
    免疫原
    KLH conjugated C-terminal peptide of Amyloid beta A4 (1-40) and beta A4 (1-42).
    克隆位点
    9F1
    亚型
    IgG1
    Top Product
    Discover our top product Abeta Primary Antibody
  • 应用备注
    Western Blot: 1 μg/mL for HRPO/ECL detection. Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubationbuffer. ELISA: 0.05 μg/mL. Immunocytochemistry: 0.1-1 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 溶解方式
    Restore with 1 mL H2O (15 min, RT).
    缓冲液
    1 mL2 x PBS containing 0.09 % Sodium Azide, PEG and Sucrose
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store lyophilized (preferably in a desiccator) at -20 °C and reconstituted (aliquote andfreeze in liquid nitrogen) at -20 °C to -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 2-8 °C up to 3 months.
    Shelf life: one year from despatch.
    有效期
    12 months
  • 抗原
    beta Amyloid (Abeta) (Amyloid beta (Abeta))
    别名
    Amyloid beta (Abeta 产品)
    别名
    AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN-II antibody, PN2 antibody, aaa antibody, abeta antibody, abpp antibody, ad1 antibody, appi antibody, ctfgamma antibody, cvap antibody, pn2 antibody, Abeta antibody, Abpp antibody, Adap antibody, Ag antibody, Cvap antibody, E030013M08Rik antibody, betaApp antibody, amyloid beta precursor protein antibody, amyloid beta (A4) precursor protein antibody, APP antibody, app antibody, App antibody
    背景
    The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).Synonyms: Amyloid beta peptide
    途径
    Inflammasome
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