HIV-1/2 Protease (HIV-1/2 p10) 抗体
Cited in 5+ publications. This 小鼠 单克隆 anti-not_set antibody (Clone 1696) specifically detects not_set in ELISA, WB 和 Func. The antibody is reactive with Human Immunodeficiency Virus (HIV) samples.
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(5 references)
产品编号 ABIN125709
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中国
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Quick Overview for HIV-1/2 Protease (HIV-1/2 p10) 抗体 (ABIN125709)
抗原
HIV-1/2 Protease (HIV-1/2 p10)
适用
Human Immunodeficiency Virus (HIV)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Western Blotting (WB), Functional Studies (Func)
克隆位点
1696
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原理
- Anti-HIV-1/HIV-2 protease Purified Azide Free
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特异性
- The antibody 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. The antibody 1696 does not react with the precursor.
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交叉反应 （详细）
- HIV
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Bacterially expressed full-length HIV-1 protease
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亚型
- IgG1
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anti-HIV-1/2 Protease (HIV-1/2 p10) antibody
HIV-1/2 p10 适用: Human Immunodeficiency Virus (HIV) ELISA, WB 宿主: 小鼠 Monoclonal 1696 unconjugated
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应用备注
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Functional application: The antibody 1696 strongly inhibits the enzyme activity of HIV-1 and HIV-2 proteases.
Western blotting: Recommended dilution: 0.5 μg/mL. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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储存液
- Azide free
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients." in: Virology, Vol. 484, pp. 127-35, (2015) (PubMed).
: "Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease." in: Virology, (2013) (PubMed).
: "Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies." in: Antiviral research, Vol. 78, Issue 3, pp. 275-7, (2008) (PubMed).
: "Diversification and specialization of HIV protease function during in vitro evolution." in: Molecular biology and evolution, Vol. 23, Issue 4, pp. 764-72, (2006) (PubMed).
: "Inhibition of the HIV-1 and HIV-2 proteases by a monoclonal antibody." in: Protein science : a publication of the Protein Society, Vol. 8, Issue 12, pp. 2686-96, (2000) (PubMed).
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: "Mutations in human immunodeficiency virus type 1 reverse transcriptase that make it sensitive to degradation by the viral protease in virions are selected against in patients." in: Virology, Vol. 484, pp. 127-35, (2015) (PubMed).
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- HIV-1/2 Protease (HIV-1/2 p10)
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别名
- HIV-1/HIV-2 protease
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物质类
- Viral Protein
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背景
- The HIV protease (PR) hydrolyzes polyproteins of HIV virus into functional protein products that are essential for its assembly and subsequent activity. This maturation process occurs as the virion buds from the host cell. HIV protease inhibitors are used in the treatment of patients with AIDS and were considered the first breakthrough in over a decade of AIDS research. HIV protease inhibitors can lower the viral load carried by AIDS patents.,HIV-1 PR, HIV-2 PR
抗原
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