CALCRL 抗体 (Cytoplasmic Domain)
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- 抗原 See all CALCRL 抗体
- CALCRL (Calcitonin Receptor-Like (CALCRL))
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抗原表位
- Cytoplasmic Domain
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CALCRL antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Reacts with Calcitonin Receptor-Like Receptor (Family: GPCR, subfamily: Adrenomedullin). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except CALCR (56 %).
- 交叉反应 （详细）
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Species reactivity (expected):Mouse (93 % identity and similarity) and Rat (100 % identity and similarity).
Species reactivity (tested):Human. - 纯化方法
- Immunoaffinity Chromatography
- 免疫原
- Synthetic peptide - KLH conjugated
- Top Product
- Discover our top product CALCRL Primary Antibody
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anti-Calcitonin Receptor-Like (CALCRL) (AA 522-536), (C-Term), (Intracellular) antibody
CALCRL 适用: 人, 小鼠, 大鼠 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 23-132) antibodyCALCRL 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 340-367) antibodyCALCRL 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22070 unconjugated
anti-Calcitonin Receptor-Like (CALCRL) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (C-Term) antibodyCALCRL 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 108-157) antibodyCALCRL 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 犬, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcitonin Receptor-Like (CALCRL) (AA 392-461) antibodyCALCRL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry with formalin fixed paraffin embedded tissues: 34 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, 0.09 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- CALCRL (Calcitonin Receptor-Like (CALCRL))
- 别名
- CGRP Type 1 Receptor / CRLR (CALCRL 产品)
- 别名
- CALCRL antibody, CGRPR antibody, CRLR antibody, AV071593 antibody, CLR antibody, Crlr antibody, RATCRLR antibody, RNCLR antibody, calcitonin receptor like receptor antibody, calcitonin receptor-like antibody, calcitonin receptor like receptor L homeolog antibody, CALCRL antibody, LOC100168906 antibody, calcrl antibody, Calcrl antibody, calcrl.L antibody
- 背景
- Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.Synonyms: CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor
- 基因ID
- 10203
- UniProt
- Q16602
- 途径
- cAMP Metabolic Process
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