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- 抗原 See all ADRB3 抗体
- ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))
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抗原表位
- Cytoplasmic Domain
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ADRB3 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Reacts with Beta-3 Adrenoceptor (Family: GPCR, Subfamily: Adrenergic)
- 纯化方法
- Peptide immunogen affinity column
- 免疫原
- Synthetic peptide - KLH conjugated
- Top Product
- Discover our top product ADRB3 Primary Antibody
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anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 310-408) antibody
ADRB3 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 1-100) antibodyADRB3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (N-Term) antibodyADRB3 适用: 人, 大鼠 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 1-408) antibodyADRB3 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (2nd Extracellular Loop), (AA 180-192), (Cys186) antibodyADRB3 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 1-36) antibodyADRB3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 216-249) antibodyADRB3 适用: 人 WB 宿主: 兔 Polyclonal RB53477 unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) (AA 255-289) antibodyADRB3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB53334 unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) antibodyADRB3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Adrenergic, beta-3-, Receptor (ADRB3) antibodyADRB3 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry on formalin fixed paraffin embedded tissues: 36 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- PBS, pH 7.7, containing 0.01 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-80 °C
- 储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - 有效期
- 12 months
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- 抗原
- ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))
- 别名
- beta-3 Adrenergic Receptor (ADRB3 产品)
- 别名
- BETA3AR antibody, Adrb-3 antibody, ADRB antibody, BAR3 antibody, B3AR antibody, GPCR antibody, im:7154935 antibody, si:ch211-215f19.1 antibody, zgc:194843 antibody, zgc:194852 antibody, adrenoceptor beta 3 antibody, adrenergic receptor, beta 3 antibody, adrenoceptor beta 3a antibody, adrenoceptor beta 3b antibody, ADRB3 antibody, Adrb3 antibody, adrb3a antibody, adrb3b antibody
- 背景
- The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility, beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure, ADRB3 is also one of the molecular targets under active research in the treatment of obesity. Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta librariesSynonyms: ADRB3, ADRB3R, B3AR, Beta-3 adrenoceptor
- 基因ID
- 155
- UniProt
- P13945
- 途径
- cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Brown Fat Cell Differentiation
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