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CXCR3 抗体 (C-Term)

This 兔 多克隆 antibody specifically detects CXCR3 in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN121951
发货至: 中国
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Quick Overview for CXCR3 抗体 (C-Term) (ABIN121951)

抗原

See all CXCR3 抗体
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

适用

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宿主

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克隆类型

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多克隆

标记

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This CXCR3 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    C-Term

    特异性

    Recognizes Human CXC Chemokine Receptor type 3 (Family: GPCR, Subfamily: Chemokine). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except SRRM2 (59 %).

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Immunoaffinity Chromatography

    免疫原

    Synthetic peptide - KLH conjugated.
  • 应用备注

    Immunohistochemistry on paraffin embedded sections: 16 μg/mL. Antigen Retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 to -70 °C forlonger. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.

    有效期

    12 months
  • 抗原

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    别名

    CD183 / CXCR3

    背景

    CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). Ligand: Interferon gamma-inducible protein 9, Interferon gamma-inducible protein 10 and Interferon gamma inducible CXC chemokines I-TAC, IP10 and Mig. An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al. 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseasess including atheroslerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.Synonyms: CXC-R3, CXCR-3, G protein-coupled receptor 9, GPR9, IP-10 receptor, IP10 receptor, Interferon-inducible protein 10 receptor

    基因ID

    2833

    UniProt

    P49682
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