CD8 抗体 (PE)
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北京 101111
Quick Overview for CD8 抗体 (PE) (ABIN120697)
抗原
See all CD8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody recognizes a conformationally-dependent epitope of CD8 antigen.
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产品特性
- Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain
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免疫原
- Crude thymus membrane fraction.
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亚型
- IgG2a
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应用备注
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Flow Cytometry analysis of human blood cells using 20 l reagent / 100 l whole blood or10^6 cells in a suspension. Does not work in Immunohistocchemistry omn paraffin sections or Western blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 0.1 mg/mL
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储存条件
- 4 °C
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储存方法
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Store at 2-8 °C. Do not freeze. Avoid prolonged exposure to light.
Shelf life: one year fromdespatch. -
有效期
- 12 months
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- CD8
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别名
- CD8
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背景
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
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基因ID
- 925
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UniProt
- P01732
抗原
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