CD47 抗体
Quick Overview for CD47 抗体 (ABIN120599)
抗原
See all CD47 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The antibody reacts with CD47 (Integrin Associated Protein), a 50-55 kDa membrane adhesion molecule (Thrombospondin Receptor, immunoglobulin supergene family) expressed on leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines.
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纯化方法
- CHT-Chromatography and Precipitation Methods
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免疫原
- COS-7 (African green monkey) cells
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亚型
- IgM
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anti-CD47 (CD47) (AA 20-140) antibody
CD47 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD47 (CD47) (AA 18-135) antibodyCD47 适用: 人 FACS, IHC, IF, ELISA, StM, Coat 宿主: 小鼠 Monoclonal CD47-3019 unconjugated
anti-CD47 (CD47) antibodyCD47 适用: 人, 小鼠 FACS, IHC, IF, StM 宿主: 小鼠 Monoclonal B6H12-2 unconjugated
anti-CD47 (CD47) (AA 241-323) antibodyCD47 适用: 小鼠, 大鼠 FACS, WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-CD47 (CD47) (AA 18-219) antibodyCD47 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD47 (CD47) (AA 18-135) antibodyCD47 适用: 人 FACS, WB, IHC, IF, ELISA, StM, Coat 宿主: 小鼠 Monoclonal CD47-2937 unconjugated
anti-CD47 (CD47) antibody (FITC)CD47 适用: 人, Pig, Non-Human Primate FACS 宿主: 小鼠 Monoclonal MEM-122 FITC
anti-CD47 (CD47) antibodyCD47 适用: 人, Pig, Non-Human Primate FACS, WB, IHC (fro) 宿主: 小鼠 Monoclonal MEM-122 unconjugated
anti-CD47 (CD47) antibodyCD47 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Monoclonal 4G11 unconjugated Recombinant Antibody
anti-CD47 (CD47) (AA 44-141) antibodyCD47 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Flow cytometry. Western blotting (non-reducing conditions). Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH ~7.4, 15 mM Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
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Store the antibody at 2 - 8 °C. Do not freeze.
Shelf Life: one year from despatch. -
有效期
- 12 months
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- CD47
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别名
- CD47
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背景
- CD47 is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein a, SIRPa), an immune inhibitory receptor on macrophages, this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.Synonyms: Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Leukocyte surface antigen CD47, MER6, OA3
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基因ID
- 961
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UniProt
- Q08722
抗原
-
